List of National and Regional Holidays of Tamil Nadu in 2022
| Holiday | Date | Day | Type | Remarks |
| New Year's Day | 2022-01-01 | Saturday | Regional | |
| Pongal | 2022-01-14 | Friday | Regional | |
| Thiruvalluvar Day | 2022-01-15 | Saturday | Regional | |
| Uzhavar Thirunal | 2022-01-16 | Sunday | Regional | |
| Thai Poosam | 2022-01-18 | Tuesday | Regional | |
| Republic Day | 2022-01-26 | Wednesday | National | |
| Telugu New Year's Day | 2022-04-02 | Saturday | Regional | |
| Tamil New year's Day and Dr. B.R. Ambedkar's BirthdayMahaveer Jayanthi | 2022-04-14 | Thursday | Regional | |
| Good Friday | 2022-04-15 | Friday | Regional | |
| May Day | 2022-05-01 | Sunday | Regional | |
| Ramzan (idu'l Fitr) | 2022-05-03 | Tuesday | Regional | |
| Bakrid (Idul Azha) | 2022-07-10 | Sunday | Regional | |
| Muharram | 2022-08-09 | Tuesday | Regional | |
| Independence Day | 2022-08-15 | Monday | National | |
| Krishna Jayanthi | 2022-08-19 | Friday | Regional | |
| Vinayakar Chaturthi | 2022-08-30 | Tuesday | Regional | |
| Gandhi Jayanthi | 2022-10-02 | Sunday | National | |
| Ayutha Pooja | 2022-10-04 | Tuesday | Regional | |
| Vijaya Dasami | 2022-10-05 | Wednesday | Regional | |
| Milad-un-Nabi | 2022-10-09 | Sunday | Regional | |
| Deepavali | 2022-10-24 | Monday | Regional | |
| Christmas | 2022-12-25 | Sunday | Regional |