List of National and Regional Holidays of Kerala in 2022
| Holiday | Date | Day | Type | Remarks |
| Mannam Jayanthi | 2022-01-02 | Sunday | Regional | |
| Republic Day | 2022-01-26 | Wednesday | National | |
| Sivarathri | 2022-03-01 | Tuesday | Regional | |
| Maundy ThursdayDr.B.R.Ambedkar Jayanthi | 2022-04-14 | Thursday | Regional | |
| Good FridayVishu | 2022-04-15 | Friday | Regional | |
| Easter | 2022-04-17 | Sunday | Regional | |
| May Day | 2022-05-01 | Sunday | Regional | |
| Id'ul Fitr (Ramzan) | 2022-05-02 | Monday | Regional | Subject to change depending on the appearance of the moon |
| Id-ul-Ad’ha (Bakrid) | 2022-07-09 | Saturday | Regional | Subject to change depending on the appearance of the moon |
| Karkkadaka Vaavu | 2022-07-28 | Thursday | Regional | |
| Muharram | 2022-08-08 | Monday | Regional | Subject to change depending on the appearance of the moon |
| Independence Day | 2022-08-15 | Monday | National | |
| Sreekrishna Jayanthi | 2022-08-18 | Thursday | Regional | |
| Ayyan Kali Jayanthi | 2022-08-28 | Sunday | Regional | |
| First Onam | 2022-09-07 | Wednesday | Regional | |
| Thiruvonam | 2022-09-08 | Thursday | Regional | |
| Third Onam | 2022-09-09 | Friday | Regional | |
| Fourth Onam Sree Narayana Guru Jayanthi | 2022-09-10 | Saturday | Regional | |
| Sree Narayana Guru Samadhi Day | 2022-09-21 | Wednesday | Regional | |
| Gandhi Jayanthi | 2022-10-02 | Sunday | National | |
| Mahanavami | 2022-10-04 | Tuesday | Regional | |
| Vijayadasami | 2022-10-05 | Wednesday | Regional | |
| Milad-i-Sherif* (Birthday of Prophet Muhammed) | 2022-10-24 | Monday | Regional | |
| Christmas | 2022-12-25 | Sunday | Regional |